Heart transplantation at 50+: Celebrations and challenges

Hematopoietic-cell transplantation at 50.

Alcohol and other drug use at school leavers' celebrations.

BACKGROUND A significant proportion of adolescents who attend celebratory events often engage in substantial alcohol and other drug use. We examined patterns, influences and impacts of drug consumption at an end of schooling life celebration. METHODS Seventeen- to 18-year-old Australians who intended to attend (n = 541) and who attended the celebration (n = 405), respectively, completed pre- ...

Challenges and Opportunities in Pediatric Heart Failure and Transplantation

91 Since the first heart transplantation procedure was performed almost 50 years ago, heart transplantation has undergone a startling transformation from an experimental, high-risk intervention to being offered as standard of care for children and adults with heart failure refractory to medical and surgical therapy. The potential for heart transplantation to treat complex congenital heart disea...

Heart Transplantation: New Realities, Challenges and Development- Demographics and Therapeutics

The first human heart transplant performed in South Africa in 1967 by Christiaan Barnard, took considerable advantage of the pioneering experimental work by Alexis Carrel, Frank Mann, Norman Shumway, and Richard Lower [1-4]. The first heart transplant recipient recovered well initially, but died of pneumonia 18 days later. Initial outcomes were poor, due to a limited understanding of early post...

Challenges and Opportunities in Pediatric Heart Failure and Transplantation

2313 The first cardiac transplant in the United States, and the second worldwide, was performed on a pediatric patient by Dr Adrian Kantrowitz in the late 1960s. Acute cellular rejection and other factors led to poor outcomes, limiting the growth of pediatric and adult cardiac transplantation programs. Cyclosporine-based immunosuppression was introduced in the 1980s, and survival dramatically i...